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Invasive candidiasis ICmainly caused by Shaved Harnosand girls. The mouse model of IC following intravenous yeast injection that mimics human skin-derived bloodstream candidiasis Shaved Harnosand girls been extensively used to study the innate immune response against IC. In this model, the microbiological progression of the infection is organ-specific, with kidney being the main target organ, associated with organ-specific innate Shaved Harnosand girls responses. Indeed, depletion of neutrophils or mononuclear phagocytes leads to accelerated mortality in the model. Of interest, neutrophils have different effects in the model depending on the phase of the infection; specifically, whereas early neutrophil presence is protective, late neutrophil accumulation mediates tissue injury and immunopathology that results in Sahved failure and mortality.

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